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PRO-304 for prevention of primary graft dysfunction
(PGD)
after lung transplant
80% identified potential donor lungs are declined. 5-10% of
procured lungs are discarded.
Largest margin for clinically meaningful improvement
Lungs
Livers
Kidneys
Hearts
In current ex-vivo lung perfusion (EVLP) standard of care, donor lungs awaiting transplant are mechanically ventilated while being perfused with a protective solution
Standard perfusion solutions have shown some success in improving outcomes from lower quality organs
Preclinical models have shown dissolving CO into perfusion solution reduces graft dysfunction in multiple organ transplant models
PRO-304 adds dissolved carbon monoxide into currently used perfusion solution to further enhance the efficacy of EVLP and enable more successful lung transplants from the current available organ pool
